AUTHOR=Yu Qiong , Tian Mengxing , Pi Guoliang , Jia Yegui , Jin Xin 

TITLE=Geriatric nutritional risk index as a predictor of prognosis in hematologic malignancies: a systematic review and meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1274592

DOI=10.3389/fnut.2023.1274592

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Objective</title><p>Recent studies have reported inconsistent results regarding the association between geriatric nutritional risk index (GNRI) and clinical outcomes in patients with hematologic malignancies (HMs). We performed a meta-analysis to evaluate the effect of low GNRI on the overall survival (OS) and progression-free survival (PFS) in patients with HMs.</p></sec><sec id="sec2"><title>Research Methods and Procedures</title><p>We conducted the research via PubMed, Embase, and Cochrane Library databases to identify trials. Exploring the association between GNRI and prognosis in patients with HMs. A meta-analysis of OS and PFS was performed. Quality In Prognostic Studies instrument and Newcastle–Ottawa quality assessment Scale were used to assess the quality of included trials.</p></sec><sec id="sec3"><title>Results</title><p>Fourteen studies enrolling 3,524 patients with HMs were included. Low GNRI was associated with shorter OS (Hazard ratio (HR) = 1.77; 95% CI = 1.44–2.18, <italic>p</italic> &lt; 0.01) and PFS (HR = 1.63; 95% CI = 1.17–2.27, <italic>p</italic> &lt; 0.01) in patients with HMs. In the subgroup analysis, GNRI was not significantly associated with prognosis in Chinese patients with HMs (OS, HR =1.33; 95% CI = 0.89–1.98, <italic>p</italic> = 0.16; PFS, HR = 1.70; 95% CI = 0.72–4.01, <italic>p</italic> = 0.23). For the subgroup with a GNRI cutoff value less than 98, there was no significant difference in PFS (HR = 1.34; 95% CI = 0.98–1.83, <italic>p</italic> = 0.06).</p></sec><sec id="sec4"><title>Conclusion</title><p>Low GNRI negatively impacted on the prognosis in patients with HMs. Prospective studies to identify the best cut-off value for GNRI are required.</p></sec>