AUTHOR=Musazadeh Vali , Alinejad Hanie , Esfahani Niloofar Kouhi , Kavyani Zeynab , Keramati Majid , Roshanravan Neda , Mosharkesh Erfan , Dehghan Parvin 

TITLE=The effect of L-carnitine supplementation on lipid profile in adults: an umbrella meta-analysis on interventional meta-analyses

JOURNAL=Frontiers in Nutrition

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1214734

DOI=10.3389/fnut.2023.1214734

ISSN=2296-861X

ABSTRACT=<sec id="sec1"><title>Introduction</title><p>Previous meta-analyses investigating the therapeutic effects of L-carnitine on lipid profiles have demonstrated inconsistent results. The present umbrella meta-analysis aimed to investigate the impact of efficacy of L-carnitine on lipid profiles in adults.</p></sec><sec id="sec2"><title>Methods</title><p>Databases including PubMed, Scopus, and Embase, Web of Science, and Google Scholar were searched up to June 2023. Meta-analysis was performed using a random-effects model.</p></sec><sec id="sec3"><title>Results</title><p>Our results from thirteen meta-analyses indicated that L-carnitine supplementation significantly total cholesterol (TC) (ES = −1.05 mg/dL, 95% CI: −1.71, −0.39; <italic>p</italic> = 0.002), triglycerides (TG) (ES = −2.51 mg/dL; 95% CI: −3.62, −1.39, <italic>p</italic> &lt; 0.001), and low-density lipoprotein-cholesterol (LDL-C) (ES = −4.81 mg/dL; 95% CI: −6.04, −3.59; p &lt; 0.001). It also increased high-density lipoprotein-cholesterol (HDL-C) (ES: 0.66 mg/dL, 95% CI: 0.20, 1.12, <italic>p</italic> = 0.005) levels.</p></sec><sec id="sec4"><title>Conclusion</title><p>The present umbrella meta-analysis suggests supplementation with L-carnitine in a dosage of more than 2 g/day can improve lipid profile. Thus, L-carnitine supplementation can be recommended as an adjuvant anti-hyperlipidemic agent.</p></sec>