AUTHOR=Liu Bin , Meng Qingfei , Gao Xin , Sun Huihui , Xu Zhixiang , Wang Yishu , Zhou Honglan TITLE=Lipid and glucose metabolism in senescence JOURNAL=Frontiers in Nutrition VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1157352 DOI=10.3389/fnut.2023.1157352 ISSN=2296-861X ABSTRACT=

Senescence is an inevitable biological process. Disturbances in glucose and lipid metabolism are essential features of cellular senescence. Given the important roles of these types of metabolism, we review the evidence for how key metabolic enzymes influence senescence and how senescence-related secretory phenotypes, autophagy, apoptosis, insulin signaling pathways, and environmental factors modulate glucose and lipid homeostasis. We also discuss the metabolic alterations in abnormal senescence diseases and anti-cancer therapies that target senescence through metabolic interventions. Our work offers insights for developing pharmacological strategies to combat senescence and cancer.