AUTHOR=Li Zhenmin , Zhao Ting , Shi Mingqin , Wei Yuanyuan , Huang Xiaoyi , Shen Jiayan , Zhang Xiaoyu , Xie Zhaohu , Huang Peidong , Yuan Kai , Li Zhaofu , Li Ning , Qin Dongdong TITLE=Polyphenols: Natural food grade biomolecules for treating neurodegenerative diseases from a multi-target perspective JOURNAL=Frontiers in Nutrition VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1139558 DOI=10.3389/fnut.2023.1139558 ISSN=2296-861X ABSTRACT=
As natural functional bioactive ingredients found in foods and plants, polyphenols play various antioxidant and anti-inflammatory roles to prevent the development of disease and restore human health. The multi-target modulation of polyphenols provides a novel practical therapeutic strategy for neurodegenerative diseases that are difficult to treat with traditional drugs like glutathione and cholinesterase inhibitors. This review mainly focuses on the efficacy of polyphenols on ischemic stroke, Parkinson's disease and Alzheimer's disease, including