AUTHOR=Musazadeh Vali , Faghfouri Amir Hossein , Zarezadeh Meysam , Pakmehr Azin , Moghaddam Pooria Taghavi , Hamedi-Kalajahi Fateme , Jahandideh Arian , Ghoreishi Zohreh 

TITLE=Remarkable impacts of probiotics supplementation in enhancing of the antioxidant status: results of an umbrella meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1117387

DOI=10.3389/fnut.2023.1117387

ISSN=2296-861X

ABSTRACT=<sec><title>Introduction</title><p>Numerous meta-analyses have demonstrated the beneficial effects of probiotics on oxidative stress biomarkers, although some studies have contradictory results. Therefore, the current research was conducted to obtain a precise and definite understanding on the impact of probiotics on oxidative stress biomarkers in adults.</p></sec><sec><title>Methods</title><p>We conducted a comprehensive systematic search of results on Scopus, PubMed, Embase, Web of Science, and Google Scholar dating up to March 2022. Fifteen meta-analyses were included in this umbrella meta-analysis. The random-effects model was employed to obtain the overall effect size. Subgroup analyses were carried out based on supplementation dosage and duration, mean age, and study population.</p></sec><sec><title>Results</title><p>Our results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ES<sub>WMD</sub> = −0.56, 95% CI: −0.72, −0.39; <italic>p</italic> &lt; 0.001, and ES<sub>SMD</sub> = −0.50, 95% CI: −0.66, −0.34; <italic>p</italic> &lt; 0.001). Moreover, the findings showed that probiotics resulted in a significant increase in total antioxidant capacity (TAC) (ES<sub>WMD</sub> = 29.18, 95% CI: 16.31, 42.04; <italic>p</italic> &lt; 0.001, and ES<sub>SMD</sub> = 0.25, 95% CI: 0.02, 0.47; <italic>p</italic> = 0.032), total glutathione (GSH) (ES<sub>WMD</sub>: 30.65; 95% CI: 16.94, 44.35, <italic>p</italic> &lt; 0.001), and nitric oxide (NO) (ES<sub>WMD</sub>: 1.48; 95% CI: 0.31, 2.65, <italic>p</italic> = 0.013; I<sup>2</sup> = 51.7%, <italic>p</italic> = 0.043).</p></sec><sec><title>Discussion</title><p>Probiotics could be considered a strong agent in the reinforcement of antioxidant status and preventing the incidence of chronic diseases.</p></sec>