AUTHOR=Kodama Naoki , Okada Hikaru , Hachisu Masakazu , Ando Miki , Ito Naoto , Nagata Kazuki , Katagiri Mayuka , Yasuda Yayoi , Hiroki Ikumi , Yashiro Takuya , Ichihara Gaku , Yamamoto Masayuki , Nishiyama Chiharu TITLE=A rose flavor compound activating the NRF2 pathway in dendritic cells ameliorates contact hypersensitivity in mice JOURNAL=Frontiers in Nutrition VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1081263 DOI=10.3389/fnut.2023.1081263 ISSN=2296-861X ABSTRACT=
Dendritic cells (DCs), which are typical antigen-presenting cells, localize to various sites in the body, particularly the front line of infection as sentinels, and are involved in innate and adaptive immune responses. Although the functions of DCs, such as pathogen-induced cytokine production and antigen-specific T cell activation, are important for host defenses against infection and tumorigenesis, the hyper- and/or extended activation of DCs leads to inflammatory and autoimmune diseases. In the present study, β-damascone, a major ingredient of rose fragrance, was selected from an aroma library as a candidate compound that suppresses antigen-induced immune responses. β-Damascone inhibited the functions of DCs, including the antigen-dependent proliferation of T cells, DC-induced Th1 development, and the TLR ligand-induced production of inflammatory cytokines by DCs. The β-damascone treatment also increased the protein level of the transcription factor NF-E2-related factor 2 (NRF2), which plays key roles in antioxidant responses, and the transcription of