AUTHOR=Chen Yi , You Ningning , Shen Chuchen , Wu Juju , Zhang Jinshun 

TITLE=Helicobacter pylori infection increases the risk of nonalcoholic fatty liver disease in diabetic population

JOURNAL=Frontiers in Nutrition

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1076579

DOI=10.3389/fnut.2023.1076579

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>The effect of <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) on nonalcoholic fatty liver disease (NAFLD) in the population is still controversial. Diabetes and NAFLD are both metabolically related diseases, and no studies have classified the population to study the effect of <italic>H. pylori</italic> infection on NAFLD in diabetics.</p></sec><sec><title>Methods</title><p>A population of people who were examined in the Taizhou Hospital Health Examination Center from 2017 to 2022 was included, and hematological indicators, body parameters, ultrasound data, and <italic>H. pylori</italic> detection by urea nitrogen test were collected from patients. All physical examination populations were divided into diabetic and non-diabetic populations.</p></sec><sec><title>Results</title><p>After multivariate logistic regression, <italic>H. pylori</italic> infection remained an independent risk factor for NAFLD in diabetics, but it had no significant effect on NAFLD in non-diabetic population. Additionally, there was a nonlinear relationship between glycosylated hemoglobin and <italic>H. pylori</italic> infection in diabetic population. Moreover, the incidence of NAFLD in diabetics increased with persistent <italic>H. pylori</italic> infection.</p></sec><sec><title>Conclusion</title><p>In the diabetic population, <italic>H. pylori</italic> infection does increase the risk of developing NAFLD. Glycemic control and eradication of <italic>H. pylori</italic> infection may have positive implications for reducing the incidence of NAFLD in diabetic population.</p></sec>