AUTHOR=Eow Shiang Yen , Gan Wan Ying , Jiang Tiemin , Loh Su Peng , Lee Ling Jun , Chin Yit Siew , Than Leslie Thian Lung , How Kang Nien , Thong Pui Ling , Liu Yanpin , Zhao Junying , Chen Lijun 

TITLE=MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.994607

DOI=10.3389/fnut.2022.994607

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>The microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.</p></sec><sec><title>Objective</title><p>The MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.</p></sec><sec><title>Methods</title><p>Pregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.</p></sec><sec><title>Discussion</title><p>This study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.</p></sec><sec><title>Clinical trial registration</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/" xmlns:xlink="http://www.w3.org/1999/xlink">https://clinicaltrials.gov/</ext-link>, identifier NCT04919265.</p></sec>