AUTHOR=Li Li-Xia , Feng Xin , Tao Meng-Ting , Paulsen Berit Smestad , Huang Chao , Feng Bin , Liu Wei , Yin Zhong-Qiong , Song Xu , Zhao Xinghong , Liang Xiao-Xia , Yin Li-Zi , Tang Hua-Qiao , Zou Yuan-Feng TITLE=Benefits of neutral polysaccharide from rhizomes of Polygonatum sibiricum to intestinal function of aged mice JOURNAL=Frontiers in Nutrition VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.992102 DOI=10.3389/fnut.2022.992102 ISSN=2296-861X ABSTRACT=

One purified neutral polysaccharide fraction was obtained from the rhizome of Polygonatum sibiricum by DEAE ion exchange and gel chromatography. Structure elucidation was performed by methanolysis, methylation, FT-IR, and NMR. The results indicated that PSP-NP was composed of 1,4-β-D-Gal,1, 4, 6-β-D-Gal, T-α-D-Man,1, 4-α-D-Glc, and T-α-D-Glc with a molecular weight of 43.0 kDa. We supplied this polysaccharide to aged mice and found it is of benefits to intestinal functions, as indicated by better tissue integrity and motility, improved oxidative stress and inflammation, reduced intestinal permeability and serum LPS level, as well as balanced gut microbial composition and short-chain fatty acids production. These results display a novel Polygonatum sibiricum polysaccharide to improve the intestinal function of aged mice, which provides pieces of evidence for its further development and utilization.