AUTHOR=Zhang Hailing , Wang Pei , Jie Yu , Sun Yimeng , Wang Xiaoyan , Fan Yu 

TITLE=Predictive value of 25-hydroxyvitamin D level in patients with coronary artery disease: A meta-analysis

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.984487

DOI=10.3389/fnut.2022.984487

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>A consensus has not been made about the predictive value of blood vitamin D level in patients with coronary artery disease (CAD). This meta-analysis aimed to assess the association between blood 25-hydroxyvitamin D level and adverse outcomes in patients with CAD.</p></sec><sec><title>Methods</title><p>Two independent authors searched the articles indexed in PubMed and Embase databases until June 28, 2022. Cohort studies or <italic>post-hoc</italic> analysis randomized trials evaluating the value of 25-hydroxyvitamin D level in predicting cardiovascular or all-cause mortality, and major adverse cardiovascular events ([MACEs] including death, non-fatal myocardial infarction, heart failure, revascularization, stroke, etc.) were included.</p></sec><sec><title>Results</title><p>The literature search identified 13 eligible studies for our analysis, including 17,892 patients with CAD. Meta-analysis showed that the pooled adjusted risk ratio (RR) was 1.60 (95% confidence intervals [CI] 1.35–1.89) for all-cause mortality, 1.48 (95% CI 1.28–1.71) for cardiovascular mortality, and 1.33 (95% CI 1.18–1.49) for MACEs. Leave-out one study sensitivity analysis suggested that the predictive values of blood 25-hydroxyvitamin D level were reliable.</p></sec><sec><title>Conclusions</title><p>Low blood 25-hydroxyvitamin D level is possibly an independent predictor of cardiovascular or all-cause mortality and MACEs in patients with CAD. Baseline 25-hydroxyvitamin D level may provide useful information in CAD patients.</p></sec>