AUTHOR=Saadati Saeede , Naseri Kaveh , Asbaghi Omid , Abhari Khadijeh , Zhang Pangzhen , Li Hua-Bin , Gan Ren-You 

TITLE=Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.977756

DOI=10.3389/fnut.2022.977756

ISSN=2296-861X

ABSTRACT=<sec><title>Objective</title><p><italic>Nigella sativa (N. sativa)</italic> from the family <italic>Ranunculaceae</italic> has medicinal properties. Previous studies have reported promising findings showing that <italic>N. sativa</italic> may benefit cardiometabolic health; however, current evidence on its cardiometabolic effects on those with prediabetes and type 2 diabetes mellitus (T2DM) is still unclear. Hence, we conducted a systematic review and meta-analysis to assess the efficacy of <italic>N. sativa</italic> on cardiometabolic parameters in population with prediabetes and T2DM.</p></sec><sec><title>Methods</title><p>PubMed/Medline, ISI Web of Science, Scopus, and Cochrane library were systematically searched up to June 20, 2022. Meta-analyses using random-effects models were used.</p></sec><sec><title>Results</title><p>Eleven randomized controlled trials (RCTs) were included in the meta-analysis. <italic>N. sativa</italic> intervention resulted in significant changes in fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), c-reactive protein (CRP), and malondialdehyde (MDA), without overall changes in glucose levels after oral glucose tolerance test (OGTT), fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), triglyceride, high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI) when compared with the control group. In subgroup analyses, <italic>N. sativa</italic> supplementation enhanced serum levels of HDL-C in subjects with baseline HDL-C lower than 40 mg/dL. Furthermore, HOMA-IR and BMI values decreased in the <italic>N. sativa</italic>-supplemented group compared with the control group, when the length of follow-up was more than 8 weeks and the dose was more than 1 g/day for <italic>N. sativa</italic> supplementation, respectively.</p></sec><sec><title>Conclusion</title><p>Our findings indicate that <italic>N. sativa</italic> supplementation may effectively improve cardiometabolic profiles in individuals with prediabetes and T2DM.</p></sec>