AUTHOR=Chen Lingli , Xu Minjie , Huang Qiqi , Liu Yuntao , Ren Wenwei 

TITLE=Clinical significance of albumin to globulin ratio among patients with stroke-associated pneumonia

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.970573

DOI=10.3389/fnut.2022.970573

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>It has been proven that the ratio of albumin to globulin (A/G) is a typical biomarker for monitoring inflammation and nutritional status. But the potential role of A/G in stroke-associated pneumonia (SAP) after acute ischemic stroke (AIS) remained unknown.</p></sec><sec><title>Patients and methods</title><p>Following inclusion criteria, 5,173 AIS patients were included and segmented into SAP (<italic>n</italic> = 897) and non-SAP (<italic>n</italic> = 4,276) groups. The differences in variables between groups were compared. The logistic regression model was used to determine the association between A/G and SAP, and a forest plot was drawn.</p></sec><sec><title>Results</title><p>Compared with the non-SAP group, the SAP group had a lower A/G level (<italic>P</italic> &lt; 0.001). Then, A/G was divided into quartiles. In comparison to Q3 (A/G = 1.25–1.39), logistic regression revealed that patients with a lower A/G (A/G ≤ 1.09) had a higher risk of SAP (OR = 1.96, 95% CI, 1.56–2.46, <italic>P</italic> &lt; 0.001). On the contrary, those with a higher A/G (A/G ≥ 1.4) had a lower SAP risk (OR = 0.73, 95% CI, 0.54–0.97, <italic>P</italic> = 0.029).</p></sec><sec><title>Conclusion</title><p>The study revealed that a low A/G level was associated with an increased SAP risk. Appropriate preventative measures for SAP should be taken in AIS patients with a low A/G level.</p></sec>