AUTHOR=Zhu Yiqun , Jing Danrong , Liang Huaying , Li Dianwu , Chang Qinyu , Shen Minxue , Pan Pinhua , Liu Hong , Zhang Yan 

TITLE=Vitamin D status and asthma, lung function, and hospitalization among British adults

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.954768

DOI=10.3389/fnut.2022.954768

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear.</p></sec><sec><title>Objective</title><p>To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults.</p></sec><sec><title>Methods</title><p>Multivariable logistic regression was applied to assess the relationship between serum vitamin D and asthma prevalence, lung function (FEV1, FVC, and FEV1/FVC), current wheeze, and asthma-linked hospitalizations in a cross-sectional study of 435,040 adults aged 37–73 years old from the UK Biobank.</p></sec><sec><title>Results</title><p>Compared to vitamin D deficiency, the odds of asthma were decreased by 6.4% [adjusted odds ratio (<italic>aOR</italic>) = 0.936; 95% <italic>CI</italic>: 0.911–0.962; <italic>p</italic> &lt; 0.001] and 9.8% (<italic>aOR</italic> = 0. 0.902; 95% <italic>CI</italic>: 0.877–0. 0.927; <italic>p</italic> &lt; 0.001) in individuals with insufficient and optimal vitamin D concentration, respectively, in the fully adjusted model. In total asthmatic patients, serum vitamin D was obviously and positively related with FEV1 (β = 1.328 ml, 95% <italic>CI</italic> = 0.575–2.080), FVC (β = 2.018 ml, 95% <italic>CI</italic> = 1.127–2.908), and FEV1/FVC (β = 0.006%, 95% <italic>CI</italic> = 0.002–0.010). Asthmatic patients whose vitamin D level was in the deficient category had 9.3–19.9% higher odds of current wheeze than insufficient categories (<italic>aOR</italic> = 0.907; 95% <italic>CI</italic>: 0.861–0.957; <italic>p</italic> &lt; 0.001) and optimal categories (<italic>aOR</italic> = 0.801; 95% <italic>CI</italic>: 0.759–0.845; <italic>p</italic> &lt; 0.001), but the relationship between vitamin D and asthma hospitalization was not significant.</p></sec><sec><title>Conclusion</title><p>Vitamin D deficiency was related to higher odds of asthma and current wheeze, and lower lung function in a large sample size study of British adults. Our results indicate a potential positive impact of serum vitamin D on asthma occurrence and disease control in adults.</p></sec>