AUTHOR=Cao Jiayuan , Bu Yushan , Hao Haining , Liu Qiqi , Wang Ting , Liu Yisuo , Yi Huaxi 

TITLE=RETRACTED: Effect and Potential Mechanism of Lactobacillus plantarum Q7 on Hyperuricemia in vitro and in vivo

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.954545

DOI=10.3389/fnut.2022.954545

ISSN=2296-861X

ABSTRACT=<p>Hyperuricemia (HUA) is a disorder of purine metabolism resulting in abnormally elevated serum uric acid (UA) concentration. It is believed that there is an association between gut microbiota and HUA, and probiotics have the potential palliative effect. However, the underlying mechanism of probiotics in ameliorating HUA remains unclear. The purpose of this study was to investigate the effect and mechanism of <italic>Lactobacillus plantarum</italic> Q7 on HUA in Balb/c mice. The results showed that <italic>L. plantarum</italic> Q7 had an excellent capability to affect UA metabolism, which could degrade nucleotides by 99.97%, nucleosides by 99.15%, purine by 87.35%, and UA by 81.30%. It was observed that <italic>L. plantarum</italic> Q7 could downregulate serum UA, blood urea nitrogen (BUN), creatinine (Cr), and xanthine oxidase (XOD) by 47.24%, 14.59%, 54.59%, and 40.80%, respectively. Oral administration of <italic>L. plantarum</italic> Q7 could restore the liver, kidney, and intestinal injury induced by HUA and the expression of metabolic enzymes and transporters to normal level. 16S rRNA sequencing analysis showed that <italic>L. plantarum</italic> Q7 treatment could restore the imbalance of species diversity, richness, and community evenness compared with the model group. The ratio of <italic>Bacteroidetes</italic> to <italic>Firmicutes</italic> was recovered nearly to the normal level by <italic>L. plantarum</italic> Q7 intervention. The dominant microorganisms of <italic>L. plantarum</italic> Q7 group contained more anti-inflammatory bacteria than those of the model group. These findings indicated that <italic>L. plantarum</italic> Q7 might regulate UA metabolism and repair the liver and kidney injury by reshaping the gut microbiota and could be used as a potential probiotic strain to ameliorate HUA.</p>