AUTHOR=Ma Yong , Fei Yanquan , Han Xuebing , Liu Gang , Fang Jun 

TITLE=Lactobacillus plantarum Alleviates Obesity by Altering the Composition of the Gut Microbiota in High-Fat Diet-Fed Mice

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.947367

DOI=10.3389/fnut.2022.947367

ISSN=2296-861X

ABSTRACT=<p>Metabolic disorders and intestinal flora imbalance usually accompany obesity. Due to its diverse biological activities, <italic>Lactobacillus plantarum</italic> is widely used to alleviate various diseases as a probiotic. Here, we show that <italic>L. plantarum</italic> can reduce the body weight of mice fed high-fat diets, reduce fat accumulation, and enhance mice glucose tolerance. Our results show that <italic>L. plantarum</italic> can significantly reduce the expression of DGAT1 and DGAT2, increase the expression of Cpt1a, and promote the process of lipid metabolism. Further data show that <italic>L. plantarum</italic> can increase the SCFA content in the colon and reverse the intestinal flora disorder caused by HFD, increase the abundance of <italic>Bacteroides</italic>, and <italic>Bifidobacteriales</italic>, and reduce the abundance of <italic>Firmicutes</italic> and <italic>Clostridiales</italic>. Finally, through Pearson correlation analysis, we found that <italic>Bacteroides</italic> and SCFAs are positively correlated, while <italic>Clostridiales</italic> are negatively correlated with SCFAs. Therefore, we believe that <italic>L. plantarum</italic> can regulate the structure of the intestinal microbial community, increase the production of SCFAs and thus regulate lipid metabolism.</p>