AUTHOR=Garrabou Glòria , García-García Francesc Josep , Presmanes Rosa Elvira , Feu Maria , Chiva-Blanch Gemma 

TITLE=Relevance of sex-differenced analyses in bioenergetics and nutritional studies

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.936929

DOI=10.3389/fnut.2022.936929

ISSN=2296-861X

ABSTRACT=<p>Sex-biased analyses still remain as one of the biggest limitations to obtain universal conclusions. In biomedicine, the majority of experimental analyses and a significant amount of patient-derived cohort studies exclusively included males. In nutritional and molecular medicine, sex-influence is also frequently underrated, even considering maternal-inherited organelles such as mitochondria. We herein illustrate with in-house original data examples of how sex influences mitochondrial homeostasis, review these topics and highlight the consequences of biasing scientific analyses excluding females as differentiated entities from males.</p>