AUTHOR=Tang Xiaolong , Liu Hanguang , Xiao Yuan , Wu Lei , Shu Peng 

TITLE=Vitamin C Intake and Ischemic Stroke

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.935991

DOI=10.3389/fnut.2022.935991

ISSN=2296-861X

ABSTRACT=<p>Vitamin C is an essential micronutrient with important antioxidant properties. Ischemic stroke is a major public health problem worldwide. Extensive evidence demonstrates that vitamin C has protective effects against cardiovascular disease, and there is a close relationship between vitamin C intake and ischemic stroke risk. Based on the evidence, we conducted this umbrella review to clarify the relationship between vitamin C intake and ischemic stroke risk from four perspectives: cellular mechanisms, animal experiments, clinical trials, and cohort studies.</p>