AUTHOR=Ye Xuewei , Pi Xionge , Zheng Wenxin , Cen Yingxin , Ni Jiahui , Xu Langyu , Wu Kefei , Liu Wei , Li Lanjuan 

TITLE=The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.899421

DOI=10.3389/fnut.2022.899421

ISSN=2296-861X

ABSTRACT=<p>The potential impacts of methanol extract from <italic>Polygonatum odoratum</italic> on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of H<sub>2</sub>S-related bacteria (e.g., <italic>Desulfovibrionaceae</italic>) and the lower level of H<sub>2</sub>S and higher contents of SCFA-related bacteria (e.g., <italic>Muribaculaceae</italic>). Taken together, the effects of methanol extract from <italic>Polygonatum odoratum</italic> are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis.</p>