AUTHOR=Zheng Liqiang , Xie Yanxia , Sun Zhaoqing , Zhang Rui , Ma Yanan , Xu Jiahui , Zheng Jia , Xu Qianyi , Li Zhao , Guo Xiaofan , Sun Guozhe , Xing Fuguo , Sun Yingxian , Wen Deliang TITLE=Serum Spermidine in Relation to Risk of Stroke: A Multilevel Study JOURNAL=Frontiers in Nutrition VOLUME=9 YEAR=2022 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.843616 DOI=10.3389/fnut.2022.843616 ISSN=2296-861X ABSTRACT=

The relationship between serum spermidine levels and future cardiovascular disease risk has not yet been well elucidated in the general population based on community studies. Using a nested case-control study, we estimated the association between serum spermidine level and future stroke. New stroke cases had higher baseline levels of spermidine than controls [182.8 (141.8–231.5) vs. 152.0 (124.3–193.0), P < 0.001]. After multivariable adjustment, individuals with spermidine ≥ 205.9 nmol/L (T3) higher risks of stroke (HR 5.02, 95% CI 1.58–16.02) with the lowest quartile (< 136.9 nmol/L) as reference. The association between serum spermidine levels and risk of stroke seemed to be consistent and was reproducible in our cross-sectional studies. In addition, comparisons of the areas under receiver operator characteristics curves confirmed that a model including spermidine had better discrimination than without (0.755 vs. 0.715, P = 0.04). Here we report a close relationship exists between serum spermidine levels and risk of stroke.