AUTHOR=Benjamim Cicero Jonas R. , Porto Andrey Alves , Valenti Vitor Engrácia , Sobrinho Andressa Crystine da Silva , Garner David M. , Gualano Bruno , Bueno Júnior Carlos Roberto 

TITLE=Nitrate Derived From Beetroot Juice Lowers Blood Pressure in Patients With Arterial Hypertension: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.823039

DOI=10.3389/fnut.2022.823039

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>Although there are a considerable number of clinical studies on nitrate (NO<sub>3</sub>) rich beetroot juice (BRJ) and hypertension, it is difficult to indicate the real effects of NO<sub>3</sub> from BRJ on the BP of hypertensive patients because there are still no estimates of the effects of NO<sub>3</sub> derived from BRJ on the BP of hypertension patients.</p></sec><sec><title>Objective</title><p>To clarify these effects, we developed a systematic literature review with a meta-analysis of randomized clinical trials (RCTs).</p></sec><sec><title>Design</title><p>The searches were accomplished through EMBASE, Cochrane Library, MEDLINE, CINAHL, Web of Science, and LILACS databases. The study included single or double-blinded RCTs and participants older than 18 years with hypertension [systolic BP (SBP) &gt; 130 mmHg and diastolic BP (DBP) &gt; 80 mmHg]. NO<sub>3</sub> BRJ was required to be consumed in a format that possibly blinded participants/researchers. These studies should also report the SBP and DBP values (mmHg) measured before and after the treatment. Risk of Bias tools and GRADE were enforced.</p></sec><sec><title>Results</title><p>Seven studies were included (218 participants). BRJ intervention time ranged from 3 to 60 days with daily dosages of 70–250 mL of BRJ. After the intervention with NO<sub>3</sub> from BRJ, SBP underwent significant changes (<italic>p</italic> &lt; 0.001) of −4.95 (95% CI: −8.88; −1.01) (GRADE: ⊕⊕⊕○ Moderate), but not for DBP (<italic>p</italic> = 0.06) −0.90 mmHg (95% CI: −3.16; 1.36) (GRADE: ⊕⊕⊕○ Moderate), compared to the control group.</p></sec><sec><title>Conclusions</title><p>The NO<sub>3</sub> derived from BRJ reduces SBP, but not DBP in patients with arterial hypertension.</p></sec><sec><title>Systematic Review Registration</title><p><ext-link ext-link-type="uri" xlink:href="https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=269339" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=269339</ext-link>.</p></sec>