AUTHOR=Wang Huiqin , Huang Jin , Ding Yanan , Zhou Jianwu , Gao Guanzhen , Han Huan , Zhou Jingru , Ke Lijing , Rao Pingfan , Chen Tianbao , Zhang Longxin 

TITLE=Nanoparticles Isolated From Porcine Bone Soup Ameliorated Dextran Sulfate Sodium-Induced Colitis and Regulated Gut Microbiota in Mice

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.821404

DOI=10.3389/fnut.2022.821404

ISSN=2296-861X

ABSTRACT=<p>Daily foods contain a great number of self-assembled nanoparticles (NPs) which were incidentally produced during food processing. These food incidental NPs can directly access the human gastrointestinal tract in high frequency and large quantities. Limited reports were focused on whether and how these food incidental NPs affected the gastrointestinal tissues and gut microbiota. In the present study, bone soup and its NPs both significantly ameliorated colitis symptoms in dextran sulfate sodium (DSS)-induced mice and inhibited the release of pro-inflammatory cytokines. They also restored intestinal microbiota dysbiosis by improving the diversity and richness of intestinal microbiota and regulating community composition, such as a remarkable increase in <italic>Muribaculaceae</italic>, <italic>Alistipes</italic>, and <italic>Alloprevotella</italic>, and a decrease in <italic>Helicobacter</italic>. Moreover, the correlation analysis showed that pro-inflammatory cytokines were negatively correlated with <italic>Muribaculaceae</italic>, <italic>Alloprevotella</italic>, and <italic>Alistipes</italic>, but positively correlated with <italic>Helicobacter</italic>. These findings suggest that the food incidental NPs can influence human health through regulating the inflammation of the gastrointestinal tissues and the gut microbiota.</p>