AUTHOR=Lu Jie , Yu Fei , Huang Jun , Yu Haitao , Li Fengying , Le Zhi’an , Cheng Yulan , Zhang Qi , Li Guiling , Xie Xinyou , Tang Huifang , Zhang Jun 

TITLE=Hypocholesterolemia and Inflammatory Biomarkers Act as Predictors of Severe Vitamin D Deficiency in Patients With Crohn’s Disease: A Clinical Analysis of 862 Patients in China

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.806887

DOI=10.3389/fnut.2022.806887

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>In this study, we enrolled 862 patients with Crohn’s disease (CD) in China to investigate the correlation between serum vitamin D (SVD) and serum lipids, inflammatory biomarkers, and important clinical parameters.</p></sec><sec><title>Materials and Methods</title><p>25(OH)D was measured by LS/MS/MS. Correlation analysis, chi-square tests, and logistic regression analysis were performed to determine the correlations between vitamin D and potential risk factors when vitamin D levels were lower than 10 ng/mL or 20 ng/mL.</p></sec><sec><title>Results</title><p>The incidence of severe vitamin D deficiency (SVD &lt; 10 ng/mL) in patients with CD was significantly higher than that in healthy controls (28.9 vs. 9.5%). Multinomial logistic regression analysis showed that penetrating disease [odds ratio (OR) = 2.18], low levels of high-density lipoprotein cholesterol (HDL) (<italic>OR</italic> = 1.91), high erythrocyte sedimentation rate (<italic>OR</italic> = 1.73), and platelet count (PLT) (<italic>OR</italic> = 2.71) were regarded as predictors of severe vitamin D deficiency, while only PLT (<italic>OR</italic> = 1.90) and HDL (<italic>OR</italic> = 1.76) were considered as predictors of mild vitamin D deficiency (SVD 10–20 ng/mL).</p></sec><sec><title>Conclusion</title><p>Our results confirm a higher incidence of severe vitamin D deficiency in patients with CD in China and show that vitamin D deficiency could result from the combined effects of penetrating disease, inflammation, and low levels of HDL.</p></sec>