AUTHOR=Younis Noor , Khan Muhammad Issa , Zahoor Tahir , Faisal Muhammad Naeem 

TITLE=Phytochemical and antioxidant screening of Moringa oleifera for its utilization in the management of hepatic injury

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1078896

DOI=10.3389/fnut.2022.1078896

ISSN=2296-861X

ABSTRACT=<sec><title>Introduction</title><p>Phytochemicals present in <italic>Moringa oleifera</italic> (<italic>M. oleifera</italic>) leaves have performed several physiological functions in human system such as anticarcinogenic, antidiabetic, antioxidant, immunomodulatory, hepatoprotective and antiatherogenic functions.</p></sec><sec><title>Methods</title><p>Phytochemical and antioxidant potential of <italic>M. oleifera</italic> leaves extracts were measured. Histopathology, biochemical analysis, and gene expression tests were performed on serum, blood, and liver in animal model.</p></sec><sec><title>Results and discussions</title><p>The toxic dose of N-acetyl-para-aminophenol (APAP) induced severe structural and functional changes in liver. Pre-treatment with <italic>M. oleifera</italic> ameliorated organ injury by normalizing the level of liver biomarkers and serum proteins. A low expression level of MAPK-8, TRAF-4, and TRAF-6 genes was observed in the <italic>M. oleifera</italic> treated group in comparison to positive control (hepatotoxic rats). <italic>M. oleifera</italic> leaves pretreatment amended APAP induced apoptosis and replenished hepatic cells. <italic>M. oleifera</italic> leaves extract as low-cost and sustainable treatment could be used in pharmaceutical industry for reducing hepatic degenerative changes in non-communicable diseases.</p></sec>