AUTHOR=Gao Ting , Liu Fupeng , Ban Bo , Hou Yue , Li Guangxin , Jiang Mingming , Yang Qing , Zhang Mei 

TITLE=Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1035853

DOI=10.3389/fnut.2022.1035853

ISSN=2296-861X

ABSTRACT=<sec><title>Background</title><p>The ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).</p></sec><sec><title>Method</title><p>This cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.</p></sec><sec><title>Results</title><p>Pearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (<italic>r</italic> = 0.170, <italic>p</italic> = 0.001), FN (<italic>r</italic> = 0.178, <italic>p</italic> &lt; 0.001), and TH (<italic>r</italic> = 0.205, <italic>p</italic> &lt; 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, <italic>p</italic> = 0.01; FN: β = 0.097, <italic>p</italic> = 0.038; TH: β = 0.145, <italic>p</italic> = 0.002).</p></sec><sec><title>Conclusion</title><p>In older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.</p></sec>