AUTHOR=Kaplan Merve , Şahutoğlu Arif Sercan , Sarıtaş Sümeyye , Duman Hatice , Arslan Ayşenur , Pekdemir Burcu , Karav Sercan 

TITLE=Role of milk glycome in prevention, treatment, and recovery of COVID-19

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1033779

DOI=10.3389/fnut.2022.1033779

ISSN=2296-861X

ABSTRACT=<p>Milk contains all essential macro and micro-nutrients for the development of the newborn. Its high therapeutic and antimicrobial content provides an important function for the prevention, treatment, and recovery of certain diseases throughout life. The bioactive components found in milk are mostly decorated with glycans, which provide proper formation and modulate the biological functions of glycosylated compounds. The glycome of milk consists of free glycans, glycolipids, and <italic>N-</italic> and <italic>O-</italic> glycosylated proteins. Recent studies have shown that both free glycans and glycan-containing molecules have antiviral characteristics based on different mechanisms such as signaling, microbiome modulation, natural decoy strategy, and immunomodulatory action. In this review, we discuss the recent clinical studies and potential mechanisms of free and conjugated glycans' role in the prevention, treatment, and recovery of COVID-19.</p>