AUTHOR=Ji Yuehong , Mao Kemin , Gao Jie , Chitrakar Bimal , Sadiq Faizan Ahmed , Wang Zhongxuan , Wu Jiangna , Xu Chao , Sang Yaxin 

TITLE=Pear pomace soluble dietary fiber ameliorates the negative effects of high-fat diet in mice by regulating the gut microbiota and associated metabolites

JOURNAL=Frontiers in Nutrition

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1025511

DOI=10.3389/fnut.2022.1025511

ISSN=2296-861X

ABSTRACT=<p>The gut microbiota and related metabolites are positively regulated by soluble dietary fiber (SDF). In this study, we explored the effects of SDF from pear pomace (PP) on the regulation of gut microbiota and metabolism in high-fat-diet-fed (HFD-fed) C57BL/6J male mice. The results showed that PP-SDF was able to maintain the HFD disrupted gut microbiota diversity with a significant increase in <italic>Lachnospiraceae</italic>_UCG-006, <italic>Akkermansia</italic>, and <italic>Bifidobacterium</italic> spp. The negative effects of high-fat diet were ameliorated by PP-SDF by regulating lipid metabolisms with a significant increase in metabolites like isobutyryl carnitine and dioscoretine. Correlation analysis revealed that gut microbiota, such as <italic>Akkermansia</italic> and <italic>Lachnospiraceae</italic>_UCG-006 in the PP-SDF intervention groups had strong positive correlations with isobutyryl carnitine and dioscoretin. These findings demonstrated that PP-SDF interfered with the host's gut microbiota and related metabolites to reduce the negative effects caused by a high-fat diet.</p>