AUTHOR=Chen Zeyu , Huang Yin , Cao Dehong , Qiu Shi , Chen Bo , Li Jin , Bao Yige , Wei Qiang , Han Ping , Liu Liangren 

TITLE=Vitamin C Intake and Cancers: An Umbrella Review

JOURNAL=Frontiers in Nutrition

VOLUME=8

YEAR=2022

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.812394

DOI=10.3389/fnut.2021.812394

ISSN=2296-861X

ABSTRACT=<p>Based on the existing systematic reviews and meta-analyses, we conducted this umbrella review aiming at evaluating the quality of evidence, validity and biases of the relationship between vitamin C (VC) intake and incidence and outcomes of multiple cancers. We identified 22 cancer outcomes within 3,562 articles. VC consumption was associated with lower incidence of bladder cancer, breast cancer, cervical tumors, endometrial cancer, esophageal cancer, gastric cancer, glioma, lung cancer, pancreatic cancer, prostate cancer, renal cell cancer, and total cancer occurrence. VC intake was also related to decreased risk of breast cancer prognosis (recurrence, cancer-specific mortality, and all-cause mortality).</p>