AUTHOR=Zhou Li , Liang Xiaoling , Xie Manling , Yin Jiawei , Huang Yue , Li Xiaoqin , Shan Zhilei , Chen Liangkai , Zhang Yan , Luo Cheng , Liu Liegang 

TITLE=A Functional Variant in SEPP1 Interacts With Plasma Selenium Concentrations on 3-Year Lipid Changes: A Prospective Cohort Study

JOURNAL=Frontiers in Nutrition

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.789577

DOI=10.3389/fnut.2021.789577

ISSN=2296-861X

ABSTRACT=<p><bold>Background:</bold> Excess selenium has been related with adverse lipid levels in previous epidemiological studies. Meanwhile, a functional variant in <italic>SEPP1</italic> (encodes selenoprotein P), namely rs7579, has been suggested to modulate lipid metabolism. However, the interactions between selenium status and rs7579 polymorphism on lipid changes remain unclear.</p><p><bold>Objective:</bold> To examine whether the associations between plasma selenium and 3-year lipid changes is modified by rs7579 polymorphism.</p><p><bold>Methods:</bold> A prospective cohort study was conducted among 1,621 individuals to examine the associations between baseline plasma selenium and 3-year lipid changes, as well as the interactions between plasma selenium and rs7579 polymorphism on lipid changes.</p><p><bold>Results:</bold> The median (interquartile range) concentration of plasma selenium was 91.68 (81.55–104.92) μg/L. Higher plasma selenium was associated with adverse 3-year lipid changes. Comparing the highest to the lowest quartiles of plasma selenium concentrations, 3-year lipid changes were elevated by 8.25% (95% CI: 1.54–14.96%) for triglycerides (<italic>P</italic> = 0.016), 5.88% (3.13–8.63%) for total cholesterol (<italic>P</italic> &lt; 0.001), 7.37% (3.07–11.67%) for low-density lipoprotein cholesterol (<italic>P</italic> = 0.0008), 6.44% (2.66–10.21%) for non-high-density lipoprotein cholesterol (<italic>P</italic> = 0.0009), 4.99% (0.62–9.36%) for total cholesterol/high-density lipoprotein cholesterol ratio (<italic>P</italic> = 0.025), and 7.00% (1.55–12.46%) for low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (<italic>P</italic> = 0.012). In analyses stratified by rs7579 genotypes, positive associations between plasma selenium concentrations and 3-year changes in triglycerides, TC, LDL-C, non-HDL-C, TC/HDL-C ratio, and LDL-C/HDL-C ratio were observed among CC genotype carriers, but negative associations between plasma selenium and TC/HDL-C ratio, and LDL-C/HDL-C ratio were observed among TT genotype carriers.</p><p><bold>Conclusions:</bold> Our findings suggested that plasma selenium was associated with 3-year lipid changes differentially by rs7579 genotypes, and higher plasma selenium was associated with adverse lipid changes among rs7579 CC genotype carriers, but not among T allele carriers.</p>