AUTHOR=Hu Jin-Peng , Zheng Ting-Ting , Zeng Bin-Fen , Wu Man-Ling , Shi Rui , Zhang Ye , Chen Li-Jiao , Cheng Wen-Jian , Liang Peng 

TITLE=Effects of Lactobacillus plantarum FZU3013-Fermented Laminaria japonica on Lipid Metabolism and Gut Microbiota in Hyperlipidaemic Rats

JOURNAL=Frontiers in Nutrition

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.786571

DOI=10.3389/fnut.2021.786571

ISSN=2296-861X

ABSTRACT=<p>In this study, we explored the effect of <italic>Lactobacillus plantarum</italic> FZU3013-fermented <italic>Laminaria japonica</italic> (LPLJ) supplementation to prevent hyperlipidaemia in rats fed with a high-fat diet (HFD). The results indicate that LPLJ supplementation improved serum and hepatic biochemical indicators (<italic>p</italic> &lt; 0.05), elevated short-chain fatty acid levels, reduced HFD-induced accumulation of lipid droplets in the liver, modulated the relative abundance of some microbial phylotypes, and reduced hyperlipidaemia in HFD-fed rats by adjusting the aminoacyl-tRNA, phenylalanine, tyrosine, and tryptophan biosynthetic pathways, as well as the phenylalanine, D-glutamine and D-glutamate, and glutathione metabolic pathways. Additionally, hepatic mRNA levels of the genes involved in lipid metabolism and bile acid homeostasis were significantly reduced by LPLJ intervention (<italic>p</italic> &lt; 0.05). These results suggest that LPLJ has a positive effect on modulating lipid metabolism and has the potential to be a functional food that can help prevent hyperlipidaemia.</p>