AUTHOR=Lin Eric Chang-Yi , Chen Shuoh-Wen , Chen Luen-Kui , Lin Ting-An , Wu Yu-Xuan , Juan Chi-Chang , Chang Yuan-I TITLE=Glucosamine Interferes With Myelopoiesis and Enhances the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells JOURNAL=Frontiers in Nutrition VOLUME=8 YEAR=2021 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.762363 DOI=10.3389/fnut.2021.762363 ISSN=2296-861X ABSTRACT=
Glucosamine (GlcN) is the most widely consumed dietary supplement and exhibits anti-inflammatory effects. However, the influence of GlcN on immune cell generation and function is largely unclear. In this study, GlcN was delivered into mice to examine its biological function in hematopoiesis. We found that GlcN promoted the production of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs), both