AUTHOR=Wang Dong-Dong , Wang Tian-Yun , Yang Yang , He Su-Mei , Wang You-Mei 

TITLE=The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients

JOURNAL=Frontiers in Nutrition

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.748075

DOI=10.3389/fnut.2021.748075

ISSN=2296-861X

ABSTRACT=<p><bold>Purpose:</bold> The study aimed to explore the effects of l-carnitine, acetyl-l-carnitine, and propionyl-l-carnitine on Body Mass in type 2 diabetes mellitus (T2DM) patients.</p><p><bold>Methods:</bold> Randomized controlled trial (RCT) studies of l-carnitine, acetyl-l-carnitine, and propionyl-l-carnitine in T2DM patients were searched. The change rates of Body Mass index (BMI) from baseline values were used as an evaluation indicator. The maximal effect (E<sub>max</sub>) model by non-linear mixed-effect modeling (NONMEM) was used as the evaluation method.</p><p><bold>Results:</bold> A total of 10 RCT studies, 1239 T2DM patients were included for analysis, including eight studies of l-carnitine, one study of acetyl-l-carnitine, and one study of propionyl-l-carnitine. The study found that l-carnitine could reduce the Body Mass of T2DM patients. Based on only one study each for acetyl-l-carnitine and propionyl-l-carnitine, no significant effects were found in acetyl-l-carnitine or propionyl-l-carnitine. In addition, in order to achieve a plateau of efficacy (80% E<sub>max</sub>), 2 g/day l-carnitine was required for at least 2 weeks.</p><p><bold>Conclusions:</bold> Two g/day l-carnitine was required for at least 2 weeks to affect Body Mass in T2DM patients, and no significant effects were found in acetyl-l-carnitine or propionyl-l-carnitine.</p>