AUTHOR=Wang Zheng , Zhao Yanchen , Jiang Yan , Chu Weihua 

TITLE=Prebiotic, Antioxidant, and Immunomodulatory Properties of Acidic Exopolysaccharide From Marine Rhodotorula RY1801

JOURNAL=Frontiers in Nutrition

VOLUME=8

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.710668

DOI=10.3389/fnut.2021.710668

ISSN=2296-861X

ABSTRACT=<p>In this study, an extracellular acidic polysaccharide (EAPS) from marine <italic>Rhodotorula</italic> sp. RY1801 was extracted, and its biological properties were investigated. EAPS is mainly composed of monosaccharides, including mannose, rhamnose, glucose, galactose, and fucose, had an average molecular weight of 5.902 × 10<sup>7</sup> Da. The results indicated that EAPS can promote the growth of <italic>Lactobacillus acidophilus</italic> and <italic>L. acidophilus plantarum</italic>. EAPS is capable of scavenging both superoxide anion and hydroxyl radicals <italic>in vitro</italic>. The highest scavenging rate of superoxide anion and hydroxyl radicals is 29 and 84%, respectively. Using <italic>in vivo</italic> model, we found that the EAPS can expand the lifespan and increase the disease resistance of <italic>Caenorhabditis elegans</italic> against <italic>Klebsiella pneumoniae</italic> infection <italic>via</italic> the DAF-2/DAF-16 pathway. These results suggested that EAPS from marine <italic>Rhodotorula</italic> sp. RY1801 could promote the growth of beneficial bacteria and can be used as an antioxidant and immunomodulator, which had considerable potential in the food and health industry.</p>