AUTHOR=Singh Yogesh , Salker Madhuri S. , Lang Florian 

TITLE=Green Tea Polyphenol-Sensitive Calcium Signaling in Immune T Cell Function

JOURNAL=Frontiers in Nutrition

VOLUME=7

YEAR=2021

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2020.616934

DOI=10.3389/fnut.2020.616934

ISSN=2296-861X

ABSTRACT=<p>Polyphenol compounds found in green tea have a great therapeutic potential to influence multiple human diseases including malignancy and inflammation. In this mini review, we describe effects of green tea and the most important component EGCG in malignancy and inflammation. We focus on cellular mechanisms involved in the modification of T cell function by green tea polyphenol EGCG. The case is made that EGCG downregulates calcium channel activity by influencing miRNAs regulating expression of the channel at the post-transcriptional level.</p>