AUTHOR=Dai Jiezhi , Yu Min , Chen Hua , Chai Yimin 

TITLE=Association Between Serum 25-OH-Vitamin D and Diabetic Foot Ulcer in Patients With Type 2 Diabetes

JOURNAL=Frontiers in Nutrition

VOLUME=7

YEAR=2020

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2020.00109

DOI=10.3389/fnut.2020.00109

ISSN=2296-861X

ABSTRACT=<p><bold>Background:</bold> Vitamin D deficiency has been associated with an increased risk in several diabetic complications. We aimed to evaluate the association between vitamin D and diabetic foot ulcer (DFU) in patients with type 2 diabetes.</p><p><bold>Methods:</bold> Fifty one patients were included in the study and divided into two groups for study of vitamin D, cholesterol, and triglycerides in blood serum on DFU. The association between vitamin D and DFU was measured by binary logistic regression analysis. The cut point of vitamin D for DFU was assessed by the receiver operating characteristic curve.</p><p><bold>Results:</bold> Levels of 25-OH-vitamin D were lower in patients with DFU than in DM group (<italic>P</italic> &lt; 0.0001). The AUC of 25-OH-vitamin D was 0.8254 and had an optimal cut point value (13.68 ng/ml) for the identification of DFU, with a sensitivity of 90% and a specificity of 66.67% in all patients. Multivariate logistic regression analysis indicated that the significant risk factors included 25-OH-vitamin D level (<italic>P</italic> = 0.001, OR = 0.618) and HDL-C level (<italic>P</italic> = 0.038, OR = 0.012).</p><p><bold>Conclusion:</bold> Low serum 25-OH-vitamin D level was associated with DFU. This indication was more specific than cholesterol and triglycerides levels.</p>