AUTHOR=Riccardi Daniela Mendes dos Reis , das Neves Rodrigo Xavier , de Matos-Neto Emidio Marques , Camargo Rodolfo Gonzalez , Lima Joanna Darck Carola Correia , Radloff Katrin , Alves Michele Joana , Costa Raquel Galvão Figuerêdo , Tokeshi Flávio , Otoch José Pinhata , Maximiano Linda Ferreira , de Alcantara Paulo Sérgio Martins , Colquhoun Alison , Laviano Alessandro , Seelaender Marilia TITLE=Plasma Lipid Profile and Systemic Inflammation in Patients With Cancer Cachexia JOURNAL=Frontiers in Nutrition VOLUME=7 YEAR=2020 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2020.00004 DOI=10.3389/fnut.2020.00004 ISSN=2296-861X ABSTRACT=

Cancer cachexia affects about 80% of advanced cancer patients, it is linked to poor prognosis and to date, there is no efficient treatment or cure. The syndrome leads to progressive involuntary loss of muscle and fat mass induced by systemic inflammatory processes. The role of the white adipose tissue (WAT) in the onset and manifestation of cancer cachexia gained importance during the last decade. WAT wasting is not only characterized by increased lipolysis and release of free fatty acids (FFA), but in addition, owing to its high capacity to produce a variety of inflammatory factors. The aim of this study was to characterize plasma lipid profile of cachectic patients and to correlate the FA composition with circulating inflammatory markers; finally, we sought to establish whether the fatty acids released by adipocytes trigger and/or contribute to local and systemic inflammation in cachexia. The study selected 65 patients further divided into 3 groups: control (N); weight stable cancer (WSC); and cachectic cancer (CC). The plasma FA profile was significantly different among the groups and was positively correlated with pro-inflammatory cytokines expression in the CC patients. Therefore, we propose that saturated to unsaturated FFA ratio may serve as a means of detecting cachexia.