AUTHOR=Bae Seul-A , Fang Ming Zhu , Rustgi Vinod , Zarbl Helmut , Androulakis Ioannis P. 

TITLE=At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications

JOURNAL=Frontiers in Nutrition

VOLUME=6

YEAR=2019

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2019.00132

DOI=10.3389/fnut.2019.00132

ISSN=2296-861X

ABSTRACT=<p>Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag, seriously impacts metabolic homeostasis. Metabolic dysfunction due to chronic misalignment of an organism's endogenous rhythms is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks and <italic>vice versa</italic>, and how human behavioral changes imposed by societal and occupational demands affect the physiological networks integrating peripheral clocks and metabolism. Finally, we discuss factors possibly contributing to inter-individual variability in response to circadian changes in the context of metabolic (dys)function.</p>