AUTHOR=Xin Lijing , Ipek Özlem , Beaumont Maurice , Shevlyakova Maya , Christinat Nicolas , Masoodi Mojgan , Greenberg Norman , Gruetter Rolf , Cuenoud Bernard 

TITLE=Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

JOURNAL=Frontiers in Nutrition

VOLUME=5

YEAR=2018

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2018.00062

DOI=10.3389/fnut.2018.00062

ISSN=2296-861X

ABSTRACT=<p>Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brain remain unclear. Here we report that ketones can increase the redox NAD<sup>+</sup>/NADH ratio in the resting brain of healthy young adults. As NAD is an important energetic and signaling metabolic modulator, these results provide mechanistic clues on how nutritional ketosis might contribute to the preservation of brain health.</p>