AUTHOR=Lai Silvia , Amabile Maria Ida , Altieri Silvia , Mastroluca Daniela , Lai Carlo , Aceto Paola , Crudo Massimiliano , D’Angelo Anna Rita , Muscaritoli Maurizio , Molfino Alessio 

TITLE=Effect of Underlying Renal Disease on Nutritional and Metabolic Profile of Older Adults with Reduced Renal Function

JOURNAL=Frontiers in Nutrition

VOLUME=4

YEAR=2017

URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2017.00004

DOI=10.3389/fnut.2017.00004

ISSN=2296-861X

ABSTRACT=<sec id="ST1"><title>Background</title><p>Chronic kidney disease is a common condition in the general population, particularly among older adults. Renal impairment is in turn associated with metabolic and nutritional derangements and with increased risk of cardiovascular disease.</p></sec><sec id="ST2"><title>Aim</title><p>To compare the metabolic, nutritional, and cardiovascular impact of reduced kidney function between patients with and without known renal disease.</p></sec><sec id="ST3"><title>Materials and Methods</title><p>We enrolled consecutive outpatients (age ≥65 years) with reduced renal function who were divided into two groups: Group A with history of renal disease and Group B with unknown renal disease. Metabolic and nutritional parameters, including involuntary body weight loss (BWL) in the previous 6 months, mineral metabolism, inflammatory indices, and left ventricular mass index (LVMI), were evaluated.</p></sec><sec id="ST4"><title>Results</title><p>A total of 76 patients were enrolled. Group A (<italic>n</italic> = 39, M: 24, F: 15) showed greater BWL with a significant reduction of 25-hydroxyvitamin D, transferrin, cholinesterase, albumin, and LVMI with respect to Group B (<italic>p</italic> &lt; 0.01). Conversely, Group B (<italic>n</italic> = 37, M: 23, F: 14) showed significantly increased intact parathyroid hormone, total cholesterol, low-density lipoprotein, triglycerides, and C-reactive protein when compared to Group A (<italic>p</italic> &lt; 0.05).</p></sec><sec id="ST5"><title>Conclusion</title><p>The positive history of renal disease may negatively impact on several metabolic and nutritional parameters related to increased cardiovascular risk among older adults.</p></sec>