AUTHOR=Varoni Elena M. , Lo Faro Alfredo Fabrizio , Sharifi-Rad Javad , Iriti Marcello TITLE=Anticancer Molecular Mechanisms of Resveratrol JOURNAL=Frontiers in Nutrition VOLUME=3 YEAR=2016 URL=https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2016.00008 DOI=10.3389/fnut.2016.00008 ISSN=2296-861X ABSTRACT=
Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only significantly present in grape products, a huge amount of preclinical studies investigated its anticancer properties in a plethora of cellular and animal models. Molecular mechanisms of resveratrol involved signaling pathways related to extracellular growth factors and receptor tyrosine kinases; formation of multiprotein complexes and cell metabolism; cell proliferation and genome instability; cytoplasmic tyrosine kinase signaling (cytokine, integrin, and developmental pathways); signal transduction by the transforming growth factor-β super-family; apoptosis and inflammation; and immune surveillance and hormone signaling. Resveratrol also showed a promising role to counteract multidrug resistance: in adjuvant therapy, associated with 5-fluoruracyl and cisplatin, resveratrol had additive and/or synergistic effects increasing the chemosensitization of cancer cells. Resveratrol, by acting on diverse mechanisms simultaneously, has been emphasized as a promising, multi-target, anticancer agent, relevant in both cancer prevention and treatment.