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MINI REVIEW article
Front. Nucl. Med.
Sec. PET and SPECT
Volume 5 - 2025 | doi: 10.3389/fnume.2025.1565906
This article is part of the Research Topic Musculoskeletal Disorders Related to Dysparathyroidism View all 3 articles
Article type: MINI REVIEW article
Provisionally accepted- 1 Slingeland Ziekenhuis, Doetinchem, Netherlands
- 2 Streekziekenhuis Koningin Beatrix, Winterswijk, Netherlands
Hyperparathyroidism disrupts the balance of physiological bone formation and resorption by upregulating osteoclast activity. This leads to hypercalcemia, resulting in osteoporosis and eventually the formation of 'brown tumors'. Currently used radiological and nuclear medicine imaging for primary hyperparathyroidism face challenges in accurately diagnosing bone-related complications. Molecular bone imaging techniques routinely consists of bone scintigraphy, with possible addition of bone-SPECT/CT. Recently, renewed interest has emerged in using Na[ 18 F]F-PET/CT. Both applications are highly sensitive to in vivo osteoblast activity. However, the latter technique offers improved spatial resolution and sensitivity, as well as shorter incubation and faster scanning. This article summarizes current limitations and potential improvements in bone-SPECT/CT and Na[ 18 F]F-PET/CT imaging in selected patients with hyperparathyroidism, compared to other relevant techniques and clinical parameters.
Keywords: Hyperparathyroidism, Bone SPECT/CT, Sodium fluoride PET/CT, Brown tumor, Benign bone disease, bone-related complications
Received: 23 Jan 2025; Accepted: 25 Mar 2025.
Copyright: © 2025 van der Bruggen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wouter van der Bruggen, Slingeland Ziekenhuis, Doetinchem, Netherlands
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