Skip to main content

CASE REPORT article

Front. Nucl. Med.
Sec. PET and SPECT
Volume 4 - 2024 | doi: 10.3389/fnume.2024.1527150

Case Report: Utility of Brain [ 18 F]FDG PET/CT in the Diagnosis of Sydenham's Chorea

Provisionally accepted
Abel DAMBRAIN Abel DAMBRAIN 1*Charles Boursot Charles Boursot 2Kevin Cohen Tannugi Kevin Cohen Tannugi 2Julien Reichart Julien Reichart 2Franck LACOEUILLE Franck LACOEUILLE 1
  • 1 Service de médecine nucléaire du CHU d'Angers, Angers, France
  • 2 Service de Médecine Nucléaire, Le Mans, Le Mans, France

The final, formatted version of the article will be published soon.

    Sydenham's chorea is an autoimmune reaction against cerebral basal ganglia associated with rheumatic fever, caused by group A beta-hemolytic streptococcus infection. Diagnosis of this condition is difficult because of significant delay between infection onset and symptoms presentation, resulting in few positive biological tests or imaging exams. We report the case of a nine-year-old boy exhibiting hemicorporal abnormal movements with tics for whom [18F]FDG PET/CT exam allowed to make the diagnosis, associated with anti-DNase B elevation. Other biology, spinal tap, EEG and imaging modality like MRI or scanner, were non-contributory.

    Keywords: PET, Sydenham, Brain, Chorea, Epilepsy

    Received: 12 Nov 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 DAMBRAIN, Boursot, Tannugi, Reichart and LACOEUILLE. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Abel DAMBRAIN, Service de médecine nucléaire du CHU d'Angers, Angers, France

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.