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CASE REPORT article

Front. Nucl. Med.
Sec. PET and SPECT
Volume 4 - 2024 | doi: 10.3389/fnume.2024.1446780

Case Report: Application of 18 F-FDG PET/CT in Identifying Plasmacytoma in Monoclonal Gammopathy Associated Peripheral Neuropathy Authors：

Provisionally accepted
Jiequn Weng Jiequn Weng 1Chong Sun Chong Sun 2*Jie Lin Jie Lin 2
  • 1 Yuyao People's Hospital, Yuyao, China
  • 2 Department of Neurology, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Peripheral neuropathy is a prevalent complication in plasma cell disorders, posing significant diagnostic and therapeutic challenges. This study presents three cases initially diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP). Despite initial symptom regression post-immunomodulatory treatment, the patients exhibited progressive neurological deficits. Advanced laboratory evaluation confirmed monoclonal protein presence, yet traditional diagnostic methods, including bone marrow biopsy and flow cytometry, yielded normal results. Utilizing 18 F-FDG PET/CT, we identified multiple hypermetabolic vertebral lesions, which upon biopsy, confirmed the diagnosis of plasmacytoma. Our findings underscore the utility of PET/CT as a reliable diagnostic tool for monoclonal gammopathy associated neuropathy, advocating for its consideration in cases with equivocal diagnosis. When the diagnosis is in doubt, biopsy of a lesion may facilitate early and accurate diagnosis, potentially influencing treatment strategies and patient outcomes.

    Keywords: Monoclonal Gammopathy Associated Peripheral Neuropathy, 18 F-FDG PET/CT, Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance, Chronic inflammatory demyelinating polyneuropathy

    Received: 10 Jun 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Weng, Sun and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chong Sun, Department of Neurology, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.