AUTHOR=Munoz Camila , Schneider Alina , Botnar René M. , Prieto Claudia TITLE=Recent advances in PET-MRI for cardiac sarcoidosis JOURNAL=Frontiers in Nuclear Medicine VOLUME=2 YEAR=2022 URL=https://www.frontiersin.org/journals/nuclear-medicine/articles/10.3389/fnume.2022.1032444 DOI=10.3389/fnume.2022.1032444 ISSN=2673-8880 ABSTRACT=

The diagnosis of cardiac sarcoidosis (CS) remains challenging. While only a small fraction of patients with systemic sarcoidosis present with clinically symptomatic CS, cardiac involvement has been associated with adverse outcomes, such as ventricular arrhythmia, heart block, heart failure and sudden cardiac death. Despite the clinical relevance of having an early and accurate diagnosis of CS, there is no gold-standard technique available for the assessment of CS. Non-invasive PET and MR imaging have shown promise in the detection of different histopathological features of CS. More recently, the introduction of hybrid PET-MR scanners has enabled the acquisition of these hallmarks in a single scan, demonstrating higher sensitivity and specificity for CS detection and risk stratification than with either imaging modality alone. This article describes recent developments in hybrid PET-MR imaging for improving the diagnosis of CS and discusses areas of future development that could make cardiac PET-MRI the preferred diagnostic tool for the comprehensive assessment of CS.