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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Neurodegeneration
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1575815
This article is part of the Research TopicAdvancing personalized diagnosis and treatment in Parkinson's Disease: Integrating biomarkers, neuroimaging, and artificial intelligenceView all 8 articles
Peak alpha Frequency and alpha Power Spectral Density as Vulnerability Markers of Cognitive Impairment in Parkinson's Disease: An Exploratory EEG Study
Provisionally accepted- 1Fujian Key Laboratory of Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China
- 2Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
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Cognitive impairment substantially impacts quality of life in Parkinson's disease (PD), yet current biomarker frameworks lack sensitivity for detecting early-stage cognitive decline. While peak alpha frequency (PAF) and alpha power spectral density (PSD) have emerged as potential electrophysiological markers, prior studies primarily focused on global cortical measures, neglecting region-specific variations that may better reflect the heterogeneous nature of PD-related cognitive impairment (PDCOG).To address this gap, we conducted the first multiregional comparative analysis of PAF and alpha PSD between PDCOG and PD with normal cognition patients (PDNC).Data from 76 participants (44 PD, 32 healthy controls) at The Affiliated
Keywords: cognitive impairment, Peak alpha frequency, power spectral density, Parkinson ' s disease, EEG
Received: 13 Feb 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Zhao, Cai, Song, Hi, Kong, Li, Xia, Wei and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiehua Xue, Fujian Key Laboratory of Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China
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