What is the role of Dopamine D2 Receptor in the Brain-Gut Axis? A narrative review of the Mechanism based on Gut Microbiota in Regulating Emotion and Behavior

Yingao Xie ¹ Yuqing Fang ^2*

• ¹ Jining Medical University, Jining, China
• ² Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China

With the progression of the brain-gut axis, the bidirectional communication mechanism between the gut microbiota-brain has gradually turned into a topic issues in emotion regulation research. The key role of the dopamine D2 receptor in this process has been centered on. Lately, evidences have indicated the significance of gut microbiota in emotion and behavior regulation, especially in the pathogenesis of neuropsychiatric disorders, like mood disorders, anxiety, and depression. The relationship between gut microbiota and brain activity has gradually emerged. Our review aims to explore the role of the dopamine D2 receptor in the brain-gut axis, focus on delving into its mechanism in emotion regulation, summarize the effect of gut microbiota on D2 receptor function, and then discuss the treatment utilization based on D2 receptor and its future research directions. Besides, evidences have also shown that the dopamine D2 receptor plays an vital role in emotion regulation, in detail, in the pathogenesis of mood disorders. The interaction between D2 receptor and gut microbiota has become an vital research realm. Notably, previous treatment strategies mainly focused on regulating emotions through D2 receptor-targeted drugs, nonetheless, these drugs are commonly accompanied by side effects. Future research should explore the po 删除[Carpe Diem]: Lately 删除[Carpe Diem]:combination of gut microbiota intervention and D2 receptor-targeted therapy to strengthen the efficacy and reduce adverse reactions.