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REVIEW article
Front. Neurosci.
Sec. Visual Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1560344
This article is part of the Research Topic Retinal Neuroprotection: Exploring Novel and Repurposed Therapeutics View all articles
Glial Connexins in Glaucoma
Provisionally accepted- Chengdu University of Traditional Chinese Medicine, Chengdu, China
Glial cells play a crucial role in maintaining central nervous system (CNS) homeostasis and facilitating the repair of neural tissue following injury. The regulation of neuroglia may serve as a safe and effective strategy for modulating neuroinflammatory responses and restoring glial homeostasis and defense functions.Given that the glial network is composed of connexin (CX) proteins, its neuroprotective role is extensive. Therefore, connexins should be considered as functional 'bridges' within this network. This review examines evidence for the active involvement of glial networks in neuroinflammation under both physiological and pathological conditions and summarizes the role of CXs in glaucoma. Finally, potential therapeutic strategies for glaucoma are explored.
Keywords: ：Glial Connexins, Glaucoma, Neuroinflammation, Cx43, gap juncation
Received: 14 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Song, Wu, Yang, Li and Duan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiuyi Song, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Junguo Duan, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.