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MINI REVIEW article
Front. Neurosci.
Sec. Neuropharmacology
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1537898
Effect and mechanism of GLP-1 on cognitive function in diabetes mellitus
Provisionally accepted- 1 The First Hospital of China Medical University, Shenyang, Liaoning Province, China
- 2 China Medical University, Shenyang, China
Background: Diabetes mellitus (DM) is a metabolic disorder associated with cognitive impairment. Glucagon-like peptide-1 (GLP-1) and its receptor (GLP-1R) have shown neuroprotective effects. Scope of Review: This review explores the impact of DM on cognitive function. Diabetes-related cognitive impairment is divided into three stages: diabetes-associated cognitive decrements, mild cognitive impairment (MCI), and dementia. GLP-1R agonists (GLP-1RAs) have many functions, such as neuroprotection, inhibiting infection, and metabolic regulation, and show good application prospects in improving cognitive function. The mechanisms of GLP-1RAs neuroprotection may be interconnected, warranting further investigation. Understanding these mechanisms could lead to targeted treatments for diabetes-related cognitive dysfunction.Major Conclusions: Therefore, this paper reviewed the regulatory effects of GLP-1 on cognitive dysfunction and its possible mechanism. Further research is required to fully explore the potential of GLP-1 and its analogs in this context.
Keywords: Glucagon-like peptide-1, Cognition impairment, Diabetes Mellitus, Mechanism, Neuroprotection
Received: 03 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Xiaoke, Zhao, LI and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yaqiu Jiang, The First Hospital of China Medical University, Shenyang, Liaoning Province, China
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