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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Translational Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1526910
Diffusion Tensor Imaging Assessments to Investigate Motor Impairment Recovery After Minor Basal Ganglia Haemorrhage Post-Stereotactic Surgery
Provisionally accepted
Changpin Liao1
Zhen Lu2
Jiancheng Liang3
Rusli Bin Nordin4*
Muhammad Fattah5
Hana Nurul5
Jing Ye1
Shengde Nong1- 1Baise City People's Hospital, Baise, China
- 2Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangx, China
- 3Youjiang Medical University for Nationalities, Baise, Guangx, China
- 4Department of Pathology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Bandar Saujana Putra, Selangor, Malaysia
- 5Faculty of Pharmacy and Biomedical Sciences, Mahsa University, Bandar Saujana Putra, Selangor, Malaysia
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Objective: To investigate the efficacy of diffusion tensor imaging (DTI) in assessing the motor impairment resulting from minor basal ganglia haemorrhage poststereotactic surgery.: A total of 104 patients with minor basal ganglia haemorrhages (haematoma volume ≤15 ml) underwent DTI within 48 hours and 1 month posttreatment. Patients were divided into two groups: 42 in the experimental group, receiving stereotactic surgery and medication, and 62 in the control group, receiving medication alone. The corticospinal tract(CST) of the posterior limb of the internal capsule was the region of interest (ROI) for assessing mean FA values on both sides. Fugl-Meyer motor function (FMF) scores were recorded within 48 hours and 1 month post-treatment, and Modified Rankin Scale (MRS) scores at 6 months.Results: After 1 month of treatment, the FA values and FMF scores for the affected side of patients in the experimental group were 0.34±0.17 and 67.84±4.72, respectively, significantly surpassing those of the control group, which were 0.21±0.06 and 45.38±2.25 (P<0.05). After 6 months of treatment, the experimental group exhibited MRS scores of 10 cases (23.81%) at grade 0, 12 cases (28.57%) at grade 1, 16 cases (38.10%) at grade 2, 2 cases (4.76%) at grade 3, 2 cases (4.76%) at grade 4, and 0 cases at grade 5. In contrast, the control group demonstrated 8 cases (12.90%) at grade 0, 12 cases (19.35%) at grade 1, 18 cases (29.03%) at grade 2, 15 cases (24.19%) at grade 3, 6 cases (9.68%) at grade 4, and 3 cases (4.84%) at grade 5.There are 18 cases (29.03%) in grade 2, 15 cases (24.19%) in grade 3, 6 cases (9.68%) in grade 4, and 3 cases (4.84%) in grade 5 within the control group. The experimental group showed a significantly better MRS score compared to the control group(P<0.05).DTI can accurately evaluate the structural integrity of the CST in patients with minor basal ganglia hemorrhages following stereotactic surgery, particularly regarding the CST pathways involved in motor control, providing valuable guidance for clinical treatment.
Keywords: basal ganglia haemorrhage, corticospinal tract, Diffusion Tensor Imaging, post-stereotactic, Surgery
Received: 25 Jan 2025; Accepted: 16 Apr 2025.
Copyright: © 2025 Liao, Lu, Liang, Bin Nordin, Fattah, Nurul, Ye and Nong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rusli Bin Nordin, Department of Pathology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Bandar Saujana Putra, Selangor, 42610, Malaysia
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