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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Autonomic Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1514513
This article is part of the Research Topic The correlation between neurological diseases and cardiovascular diseases View all articles
Efficacy of Cardioneurablation for Vasodepressor Vasovagal Syncope
Provisionally accepted
Zhenhuan Chen 
Ying Li 
Yuan Liu 
Guowang Shen Ganwei Xiong Bo Wu Yanfeng Liu Xiantao Huang Hongyan Li Haiwen Zhou 
Zhicheng Xu Gulao Zhang Yu Tao Fanzhi Zhang Hengli Lai *- Jiangxi Provincial People's Hospital, Nanchang, China
Cardioneuroablation (CNA) is effective for cardiac inhibitory and mixed vasovagal syncope (VVS) but not for vasodepressor VVS. This study aimed to assess the therapeutic benefits of CNA in vasodepressor VVS. Methods VVS patients hospitalized in the Department of Cardiology of Jiangxi Provincial People's Hospital were retrospectively reviewed. Holter monitoring was performed before, during, and 3 months after CNA. Changes in heart rate and atrioventricular conduction before and after ablation were compared.Thirty-five patients (18M/17F, 47.48 ± 16.49 years) were included. Median duration of syncope was 24.0 months (range, 2.5-66.0). Median number of syncope episodes before treatment was two (range, 2-4). The time domain indexes of heart rate variability, mean heart rate, maximum heart rate, and minimum heart rate were significantly higher 3 months after CNA. Mean follow-up was 11 ± 4.67 months. Recurrent syncope occurred in two patients with vasodepressor VVS, one of them with presyncope symptoms in vasodepressor type; and one patient occurred with mixed VVS, without presyncope symptoms. The syncope free survival is 76.92%. No serious complications occurred. CNA is safe and effective in the treatment of vasodepressor VVS. Conclusions CNA is effective for treating vasodepressor VVS. Our study provides a theoretical basis for individualization of treatment in patients with vasodepressor VVS.
Keywords: vasovagal syncope, Left atrial vagal plexus, high frequency stimulation, Radiofrequency ablation, Heart rate variability
Received: 21 Oct 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Chen, Li, Liu, Shen, Xiong, Wu, Liu, Huang, Li, Zhou, Xu, Zhang, Tao, Zhang and Lai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hengli Lai, Jiangxi Provincial People's Hospital, Nanchang, China
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