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REVIEW article
Front. Neurosci.
Sec. Auditory Cognitive Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1507363
This article is part of the Research Topic Impact of Acoustic Environments and Noise on Auditory Perception View all 7 articles
Research progress in modulating the auditory system by the cochlear circadian clock system in response to noise exposure
Provisionally accepted
Xiaoqiong Song 1
Mengzhu Cheng 2
Cui Gu 2 Fenghan Wang 2
Kefeng Ma 2
Chunping Wang 1 Xiaojun She 2*
Bo Cui 2*- 1 Shandong Second Medical University, Weifang, Shandong Province, China
- 2 Tianjin Institute of Health and Environmental Medicine, Beijing, China
The circadian clock is an endogenous system evolved to adapt to environmental changes. Recent studies confirmed that the cochlea exhibits circadian oscillations regulating auditory function. These oscillations are linked to brain-derived neurotrophic factor and glucocorticoid levels. Circadian rhythms influence cochlear sensitivity to noise by regulating the secretion of brain-derived neurotrophic factors and glucocorticoids. This study explores the regulatory mechanism of the circadian clock system, its impact on the auditory system, and its potential role in noise-induced hearing loss. Understanding the regulatory mechanisms of circadian rhythms in auditory function will provide new ideas for developing treatments for noise-induced hearing loss.
Keywords: Cochlea, Circadian clock, Circadian Rhythm, Noise, noise-induced hearing loss
Received: 07 Oct 2024; Accepted: 05 Mar 2025.
Copyright: © 2025 Song, Cheng, Gu, Wang, Ma, Wang, She and Cui. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaojun She, Tianjin Institute of Health and Environmental Medicine, Beijing, China
Bo Cui, Tianjin Institute of Health and Environmental Medicine, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.